Gene name:
CAPN6 (CALPM;CANPX) ;
Protein name:
Calpain-6 ;
Alternative:
Calpamodulin (CalpM) ;Calpain-like protease X-linked ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (via domain III) with microtubules (By similarity). Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger).
Function:
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues.
Subcellular Location:
Cytoplasm
perinuclear region
Cytoplasm
cytoskeleton
spindle
During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.
Protein Attributes:
50:
MGPPLKLFKN | QKYQELKQEC | IKDSRLFCDP | TFLPENDSLF | YNRLLPGKVV |
100:
WKRPQDICDD | PHLIVGNISN | HQLTQGRLGH | KPMVSAFSCL | AVQESHWTKT |
150:
IPNHKEQEWD | PQKTEKYAGI | FHFRFWHFGE | WTEVVIDDLL | PTINGDLVFS |
200:
FSTSMNEFWN | ALLEKAYAKL | LGCYEALDGL | TITDIIVDFT | GTLAETVDMQ |
250:
KGRYTELVEE | KYKLFGELYK | TFTKGGLICC | SIESPNQEEQ | EVETDWGLLK |
300:
GHTYTMTDIR | KIRLGERLVE | VFSAEKVYMV | RLRNPLGRQE | WSGPWSEISE |
350:
EWQQLTASDR | KNLGLVMSDD | GEFWMSLEDF | CRNFHKLNVC | RNVNNPIFGR |
400:
KELESVLGCW | TVDDDPLMNR | SGGCYNNRDT | FLQNPQYIFT | VPEDGHKVIM |
450:
SLQQKDLRTY | RRMGRPDNYI | IGFELFKVEM | NRKFRLHHLY | IQERAGTSTY |
500:
IDTRTVFLSK | YLKKGNYVLV | PTMFQHGRTS | EFLLRIFSEV | PVQLRELTLD |
550:
MPKMSCWNLA | RGYPKVVTQI | TVHSAEDLEK | KYANETVNPY | LVIKCGKEEV |
600:
RSPVQKNTVH | AIFDTQAIFY | RRTTDIPIIV | QVWNSRKFCD | QFLGQVTLDA |
641:
DPSDCRDLKS | LYLRKKGGPT | AKVKQGHISF | KVISSDDLTE | L
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Calpain-6
ELISA Kit for Human Calpain-6
ELISA Kit for Human Calpain-6
CLIA Kit for Human Calpain-6
CLIA Kit for Human Calpain-6
CLIA Kit for Human Calpain-6
Polyclonal Antibody for Human Calpain-6
Polyclonal Antibody for Human Calpain-6
Polyclonal Antibody for Human Calpain-6
Monoclonal Antibody for Human Calpain-6
Monoclonal Antibody for Human Calpain-6
Monoclonal Antibody for Human Calpain-6
Protein for Human Calpain-6
Protein for Human Calpain-6
Protein for Human Calpain-6
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Placenta .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] ARG-358